Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KRAS | P01116 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602168 | 0.89 | ALDH1A1 (0.53) | KDM4EALDH1A1HTTTSHRSMN1; SMN2 | |
| SCHEMBL4603128 | 0.82 | BLM (0.52) | KDM4EALDH1A1HTTTSHRSMN1; SMN2 | |
| SCHEMBL4602793 | 0.78 | KDM4E (0.51) | KDM4EALDH1A1HTT | |
| SCHEMBL1512564 | 0.77 | MEN1 (0.67) | KDM4EALDH1A1TSHRSMN1; SMN2NPC1 | |
| SCHEMBL20192506 | 0.75 | CA12 (0.55) | — | |
| SCHEMBL21650947 | 0.74 | HSD11B1 (0.63) | KDM4EALDH1A1TSHRSMN1; SMN2NPC1 | |
| SCHEMBL20192550 | 0.73 | GPR183 (0.57) | — | |
| SCHEMBL28424017 | 0.73 | IDO1 (0.49) | KDM4EALDH1A1 | |
| SCHEMBL11888875 | 0.73 | ALDH1A1 (0.54) | KDM4EALDH1A1 | |
| SCHEMBL5519966 | 0.72 | ALDH1A1 (0.69) | KDM4EALDH1A1HTTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761520-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2008-07-09 | — | — | EP | disclosed |