Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4558064 | 0.82 | TAS1R3 (0.60) | L3MBTL1TDP1POLBCYP3A4CYP2C19 | |
| SCHEMBL27431292 | 0.78 | NPC1 (0.55) | L3MBTL1TDP1POLBCYP3A4CYP2C19 | |
| SCHEMBL3830412 | 0.76 | LMNA (0.56) | L3MBTL1LMNAGAAALDH1A1KMT2A | |
| SCHEMBL4606285 | 0.75 | F10 (1.00) | F10 | |
| SCHEMBL23657718 | 0.74 | NPY5R (0.57) | L3MBTL1TDP1NAMPTLMNAGAA | |
| SCHEMBL4111979 | 0.73 | TDP1 (0.62) | L3MBTL1TDP1POLBLMNAGAA | |
| SCHEMBL11350319 | 0.73 | ACE (0.59) | L3MBTL1TDP1POLBLMNAALDH1A1 | |
| SCHEMBL3840630 | 0.71 | ACE (0.61) | L3MBTL1TDP1POLBLMNAALDH1A1 | |
| SCHEMBL4573235 | 0.71 | ACE (0.61) | L3MBTL1TDP1POLBLMNAALDH1A1 | |
| SCHEMBL8908771 | 0.71 | ACE (0.61) | L3MBTL1TDP1POLBLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948639-A2 | NOVEL CARBOCYCLIC FUSED CYCLIC AMINES | F. Hoffmann-la Roche AG (CH) | 2008-07-30 | — | — | EP | claimed |
| WO-2007054453-A2 | CARBOCYCLIC FUSED CYCLIC AMINES AS INHIBITORS OF THE COAGULATION FACTOR XA | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-18 | — | — | WO | claimed |