Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 10/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896746 | 0.88 | CYP11B2 (0.42) | CYP11B2CYP11B1ALOX5APUSP2HTT | |
| SCHEMBL17896750 | 0.83 | CYP11B2 (0.43) | CYP11B2CYP11B1ALOX5APUSP2HTT | |
| SCHEMBL10175792 | 0.81 | CYP11B2 (0.46) | CYP11B2CYP11B1ALOX5APRAB9AUSP2 | |
| SCHEMBL459209 | 0.80 | PTGS2 (0.48) | CYP11B2CYP11B1ALOX5APRAB9AUSP2 | |
| SCHEMBL458763 | 0.79 | CYP11B2 (0.43) | CYP11B2CYP11B1ALOX5APRAB9AUSP2 | |
| SCHEMBL7371256 | 0.70 | MKNK1 (0.42) | CYP11B2CYP11B1PDE2APDE10APDE5A | |
| SCHEMBL17896748 | 0.69 | USP2 (0.47) | CYP11B2CYP11B1ALOX5APRAB9AUSP2 | |
| SCHEMBL17896749 | 0.68 | CYP11B2 (0.45) | CYP11B2CYP11B1ALOX5APRAB9AUSP2 | |
| SCHEMBL17896747 | 0.68 | PTGS2 (0.46) | CYP11B2CYP11B1ALOX5APUSP2HTT | |
| SCHEMBL10175817 | 0.67 | RAD51 (0.60) | CYP11B2CYP11B1RAB9ANPC1RAD51 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| EP-2595482-A1 | ALDOSTERONE SYNTHASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |