Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | BRS3 | P32247 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | WDR5 | P61964 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ATP1A1 | P05023 | 2/20 | 0.42 |
| ▸ | ATP1B1 | P05026 | 2/20 | 0.42 |
| ▸ | ATP1A3 | P13637 | 2/20 | 0.42 |
| ▸ | ATP1B2 | P14415 | 2/20 | 0.42 |
| ▸ | ATP4A | P20648 | 2/20 | 0.42 |
| ▸ | ATP1A2 | P50993 | 2/20 | 0.42 |
| ▸ | ATP4B | P51164 | 2/20 | 0.42 |
| ▸ | ATP1B3 | P54709 | 2/20 | 0.42 |
| ▸ | FXYD2 | P54710 | 2/20 | 0.42 |
| ▸ | ATP1A4 | Q13733 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5988718 | 0.85 | AGXT (0.42) | KMT2AMEN1BRS3ALDH1A1WDR5 | |
| SCHEMBL30065339 | 0.85 | AGXT (0.42) | KMT2AMEN1BRS3ALDH1A1WDR5 | |
| SCHEMBL29687325 | 0.85 | HPGD (0.41) | ALDH1A1HPGDHSD17B10AGXTFGFR1 | |
| SCHEMBL6456630 | 0.81 | FGFR1 (0.41) | KMT2AMEN1BRS3ALDH1A1WDR5 | |
| SCHEMBL21029237 | 0.78 | KMT2A (0.45) | KMT2AMEN1BRS3ALDH1A1WDR5 | |
| SCHEMBL2592828 | 0.78 | KMT2A (0.45) | KMT2AMEN1BRS3ALDH1A1WDR5 | |
| SCHEMBL14344286 | 0.78 | KMT2A (0.45) | KMT2AMEN1BRS3ALDH1A1WDR5 | |
| SCHEMBL3386628 | 0.77 | KMT2A (0.44) | KMT2AMEN1BRS3ALDH1A1WDR5 | |
| SCHEMBL18710710 | 0.77 | KMT2A (0.44) | KMT2AMEN1BRS3ALDH1A1WDR5 | |
| SCHEMBL3386622 | 0.77 | KMT2A (0.44) | KMT2AMEN1BRS3ALDH1A1WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499125-B1 | PROCESS FOR THE RESOLUTION OF OMEPRAZOLE | HETERO RESEARCH FOUNDATION (IN) | 2016-01-27 | — | — | EP | claimed |
| US-7332505-B2 | Nitrosated and nitrosylated proton pump inhibitors, compositions and methods of use | NITROMED, INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-20070179150-A1 | NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2007-08-02 | — | — | US | disclosed |
| US-7211590-B2 | Nitrosated proton pump inhibitors, compositions and methods of use | NITROMED, INC. (US) | 2007-05-01 | — | — | US | disclosed |
| EP-1534278-A4 | NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED INC (US) | 2006-09-06 | — | — | EP | disclosed |
| EP-1534278-A2 | NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | Nitromed, Inc. (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1154771-A4 | NITROSATED AND NITROSYLATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED INC (US) | 2005-04-20 | — | — | EP | disclosed |
| US-6852739-B1 | Methods using proton pump inhibitors and nitric oxide donors | NITROMED INC. (US) | 2005-02-08 | — | — | US | disclosed |
| US-20040266828-A1 | Nitrosated and nitrosylated proton pump inhibitors, compositions and methods of use | NITROMED, INC. (US) | 2004-12-30 | — | — | US | disclosed |
| WO-2004012659-A2 | NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2004-02-12 | — | — | WO | disclosed |
| US-20040024014-A1 | Nitrosated proton pump inhibitors, compositions and methods of use | NITROMED, INC. (US) | 2004-02-05 | — | — | US | disclosed |
| EP-1154771-A1 | NITROSATED AND NITROSYLATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | Nitromed, Inc. (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050037-A1 | NITROSATED AND NITROSYLATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2000-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179150-A1 | NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE | NOS1, PTGS1, NOS2 | KMT2A 4456/4885MEN1 3204/4885BRS3 550/4885 |
| US-20040024014-A1 | Nitrosated proton pump inhibitors, compositions and methods of use | NOS1, PTGS1, NOS2 | KMT2A 4456/4885MEN1 3204/4885BRS3 550/4885 |
| US-20040266828-A1 | Nitrosated and nitrosylated proton pump inhibitors, compositions and methods of use | NOS2, NOS1, PTGS2 | KMT2A 2820/4885MEN1 2357/4885BRS3 391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.