Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.39 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.39 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4604360 | 0.97 | MAPK1 (0.47) | MAPK1PKMHSD17B10ALDH1A1GAA | |
| SCHEMBL4604514 | 0.97 | MAPK1 (0.47) | MAPK1PKMHSD17B10ALDH1A1GAA | |
| SCHEMBL4604596 | 0.93 | MAPK1 (0.40) | MAPK1PKMHSD17B10ALDH1A1GAA | |
| SCHEMBL4605100 | 0.90 | MAPK1 (0.40) | MAPK1PKMHSD17B10ALDH1A1GAA | |
| SCHEMBL4604012 | 0.90 | MAPK1 (0.40) | MAPK1PKMHSD17B10ALDH1A1GAA | |
| SCHEMBL4605665 | 0.89 | ALDH1A1 (0.41) | MAPK1PKMHSD17B10ALDH1A1GAA | |
| SCHEMBL4603167 | 0.87 | ALDH1A1 (0.49) | MAPK1ALDH1A1KDM4EKMT2ATSHR | |
| SCHEMBL4604896 | 0.86 | ALDH1A1 (0.41) | MAPK1PKMHSD17B10ALDH1A1GAA | |
| SCHEMBL4603927 | 0.86 | MAPK1 (0.48) | MAPK1PKMHSD17B10ALDH1A1GAA | |
| SCHEMBL4605147 | 0.86 | MAPK1 (0.48) | MAPK1PKMHSD17B10ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139710-B2 | Aliphatic polyester resin compositions, molded articles of aliphatic polyester resin and method of producing same | TAKEMOTO YUSHI KABUSHIKI KAISHA (JP) | 2015-09-22 | — | — | US | disclosed |
| EP-1707598-B1 | ALIPHATIC POLYESTER RESIN COMPOSITION, ALIPHATIC POLYESTER RESIN MOLDING AND PROCESS FOR PRODUCING THE ALIPHATIC POLYESTER RESIN MOLDING | TAKEMOTO OIL & FAT CO LTD (JP) | 2008-07-09 | — | — | EP | disclosed |
| US-20070270535-A1 | Aliphatic Polyester Resin Compositions, Molded Articles of Aliphatic Polyester Resin and Method of Producing Same | TAKEMOTO YUSHI KABUSHIKI KAISHA (JP) | 2007-11-22 | — | — | US | disclosed |
| EP-1707598-A1 | ALIPHATIC POLYESTER RESIN COMPOSITION, ALIPHATIC POLYESTER RESIN MOLDING AND PROCESS FOR PRODUCING THE ALIPHATIC POLYESTER RESIN MOLDING | Takemoto Yushi Kabushiki Kaisha (JP) | 2006-10-04 | — | — | EP | disclosed |