Zaltidine

Zaltidine

SCHEMBL4606700

Cc1nc(-c2csc(N=C(N)N)n2)c[nH]1

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ATP4A P20648 18/20 0.63
ATP4B P51164 18/20 0.63
MAPT P10636 3/20 0.56
NPC1 O15118 2/20 0.56
RAB9A P51151 2/20 0.56
GFER P55789 1/20 0.56
NPSR1 Q6W5P4 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9292234 0.85 ATP4A (0.54) ATP4AATP4BMAPTNPC1RAB9A
SCHEMBL11021937 0.74 ATP4A (0.54) ATP4AATP4BMAPTNPC1RAB9A
Zaltidine SCHEMBL534302 0.74 ATP4A (0.54) ATP4AATP4BMAPTNPC1RAB9A
Zaltidine SCHEMBL635743 0.72 ATP4A (0.53) ATP4AATP4BMAPTNPC1RAB9A
SCHEMBL9298276 0.71 ATP4A (0.57) ATP4AATP4BMAPTNPC1RAB9A
SCHEMBL6985595 0.71 MAPT (0.57) ATP4AATP4BMAPTNPC1RAB9A
Bromide SCHEMBL826907 0.71 MAPT (0.97) ATP4AATP4BMAPTNPC1RAB9A
Zaltidine SCHEMBL3605309 0.71 ATP4A (0.39) ATP4AATP4BNPC1RAB9A
SCHEMBL9297745 0.70 ATP4A (0.55) ATP4AATP4BMAPTNPC1RAB9A
Hydrochloric Acid SCHEMBL9298145 0.70 ATP4A (0.56) ATP4AATP4BMAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8277782-B2 Antiinflammatory agent, metalloproteinase inhibitor, anti-oxidant and modifier of cell redox status, vitamins, inhibitor of activation of nuclear factor kappa beta THE PROCTER & GAMBLE COMPANY (US) 2012-10-02 US disclosed
EP-1294367-B1 ORAL COMPOSITIONS COMPRISING HOST-RESPONSE MODULATING AGENT PROCTER & GAMBLE (US) 2008-07-16 EP disclosed
US-20060193790-A1 Promoting whole body health THE PROCTER & GAMBLE COMPANY 2006-08-31 US disclosed
US-20050042283-A1 Histamine and CCK2/gastrin receptor blockade in the treatment of acid-peptic disease and cancer UNIVERSITY OF MASSACHUSETTS (US) 2005-02-24 US disclosed
WO-2005007107-A2 HISTAMINE AND CCK2/GASTRIN RECEPTOR BLOCKADE IN THE TREATMENT OF ACID-PEPTIC DISEASE AND CANCER UNIVERSITY OF MASSACHUSETTS (US) 2005-01-27 WO disclosed
EP-1189662-A1 COMBINATION FOR TREATING WEIGHT GAIN ASSOCIATED WITH ANTIPSYCHOTIC USE COMPRISING AN ATYPICAL ANTIPSYCHOTIC AND AN H2 ANTAGONIST ELI LILLY AND COMPANY (US) 2002-03-27 EP disclosed
WO-2000074784-A1 COMBINATION FOR TREATING WEIGHT GAIN ASSOCIATED WITH ANTIPSYCHOTIC USE COMPRISING AN ATYPICAL ANTIPSYCHOTIC AND AN H2 ANTAGONIST ELI LILLY AND COMPANY (US) 2000-12-14 WO disclosed
US-5364616-A Use of H-2 antagonists for treatment of gingivitis THE PROCTER & GAMBLE COMPANY (US) 1994-11-15 US disclosed
US-5294433-A Dentistry THE PROCTER & GAMBLE COMPANY (US) 1994-03-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060193790-A1 Promoting whole body health IFNG, TNF, TLR6 ATP4A 2406/4885ATP4B 3360/4885MAPT 4679/4885
US-20050042283-A1 Histamine and CCK2/gastrin receptor blockade in the treatment of acid-peptic disease and cancer HRH2, CCKBR, GRPR ATP4A 1168/4885ATP4B 1661/4885MAPT 4814/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.