Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TACR3 | P29371 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4588810 | 0.80 | CYP2C19 (0.47) | CYP2C19HTTALDH1A1MMP1MMP2 | |
| SCHEMBL4589971 | 0.78 | ALDH1A1 (0.37) | CYP2C19MAPTMEN1LMNAKMT2A | |
| SCHEMBL17465167 | 0.74 | HCAR2 (0.50) | MAPTTACR3MEN1LMNAKMT2A | |
| SCHEMBL27666225 | 0.74 | HCAR2 (0.50) | MAPTTACR3MEN1LMNAKMT2A | |
| SCHEMBL27720282 | 0.73 | MAPT (0.39) | CYP2C19MAPTTACR3MEN1LMNA | |
| SCHEMBL27741031 | 0.73 | MAPT (0.39) | CYP2C19MAPTTACR3MEN1LMNA | |
| Methane SCHEMBL27462948 | 0.73 | MAPT (0.43) | MAPTTACR3MEN1LMNAKMT2A | |
| SCHEMBL28862367 | 0.71 | MAPT (0.47) | MAPTTACR3MEN1LMNAKMT2A | |
| SCHEMBL20482479 | 0.71 | KMT2A (0.48) | CYP2C19MAPTTACR3MEN1LMNA | |
| SCHEMBL17844765 | 0.71 | MAPT (0.43) | MAPTTACR3MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937656-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS BETA 2 ADRENOCEPTOR AGONISTS | AstraZeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007027134-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2007-03-08 | — | — | WO | disclosed |