Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4589967 | 0.82 | HTT (0.44) | ALDH1A1KMT2ASMN1; SMN2CYP2C19MEN1 | |
| SCHEMBL4606802 | 0.78 | CYP2C19 (0.42) | ALDH1A1KMT2ASMN1; SMN2CYP2C19MEN1 | |
| SCHEMBL4375323 | 0.71 | CYP2C19 (0.49) | ALDH1A1KMT2ASMN1; SMN2CYP2C19MEN1 | |
| SCHEMBL14763225 | 0.70 | SCN9A (0.47) | ALDH1A1CYP2C19CYP3A4CYP2C9SCN9A | |
| SCHEMBL14763226 | 0.70 | SCN9A (0.47) | ALDH1A1CYP2C19CYP3A4CYP2C9SCN9A | |
| SCHEMBL29281331 | 0.70 | CYP2D6 (0.43) | ALDH1A1SMN1; SMN2CYP2C19KDM4ECYP3A4 | |
| SCHEMBL28359858 | 0.70 | SCN9A (0.48) | CYP3A4SCN9AMAPTNPC1RAB9A | |
| SCHEMBL3463433 | 0.69 | ALDH1A1 (0.43) | ALDH1A1KMT2ASMN1; SMN2CYP2C19MEN1 | |
| SCHEMBL27720282 | 0.69 | MAPT (0.39) | ALDH1A1KMT2ACYP2C19MEN1CYP3A4 | |
| SCHEMBL27741031 | 0.69 | MAPT (0.39) | ALDH1A1KMT2ACYP2C19MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937656-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS BETA 2 ADRENOCEPTOR AGONISTS | AstraZeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007027134-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2007-03-08 | — | — | WO | disclosed |