Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 3/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F12 | P00748 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | OTC | P00480 | 1/20 | 0.43 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | C1S | P09871 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.41 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL4606882 | 1.00 | F10 (0.44) | F10F2F12F7F3 | |
| Arginine SCHEMBL12006798 | 0.92 | OTC (0.43) | OTCKMT2APOLBTDP1DDAH1 | |
| Arginine SCHEMBL1287134 | 0.92 | OTC (0.43) | OTCKMT2APOLBTDP1DDAH1 | |
| Arginine SCHEMBL28911624 | 0.91 | OTC (0.41) | F10OTCPRSS1KMT2APOLB | |
| Arginine SCHEMBL28911606 | 0.91 | OTC (0.41) | F10OTCPRSS1KMT2APOLB | |
| Arginine SCHEMBL28911625 | 0.90 | OTC (0.43) | OTCKMT2APOLBTDP1DDAH1 | |
| Arginine SCHEMBL28268971 | 0.88 | OTC (0.53) | OTCBLMKMT2ADDAH1 | |
| Arginine SCHEMBL31315051 | 0.88 | CA2 (0.44) | OTCKMT2APOLBTDP1DDAH1 | |
| Arginine SCHEMBL26914670 | 0.87 | KIF11 (0.46) | OTCKMT2APOLBTDP1DDAH1 | |
| Arginine SCHEMBL2485033 | 0.87 | OTC (0.43) | OTCPRSS1KMT2APOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008120098-A2 | PEPTIDE PRODRUGS | DIATOS (FR) | 2008-10-09 | — | — | WO | disclosed |
| EP-1977765-A1 | Peptide prodrugs | Diatos (FR) | 2008-10-08 | — | — | EP | disclosed |