Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.46 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 6/20 | 0.44 |
| ▸ | FAAH | O00519 | 4/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4607189 | 0.81 | CES1 (0.42) | FABP4HDAC1HDAC2CES1FAAH | |
| SCHEMBL4156249 | 0.78 | LMNA (0.58) | HDAC1HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL4165180 | 0.76 | HDAC3 (0.58) | HDAC1HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL4164039 | 0.75 | HDAC1 (0.41) | HDAC1HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL4605614 | 0.73 | CES1 (0.45) | FABP4HDAC1HDAC2HDAC8HDAC3 | |
| Trifluoroacetic Acid SCHEMBL4166937 | 0.72 | FABP4 (0.36) | FABP4HDAC1HDAC2HDAC4CES1 | |
| SCHEMBL8614195 | 0.70 | L3MBTL1 (0.59) | L3MBTL1 | |
| SCHEMBL30764851 | 0.70 | L3MBTL1 (0.59) | L3MBTL1 | |
| SCHEMBL4168896 | 0.70 | CES1 (0.39) | FABP4HDAC1HDAC2CES1FAAH | |
| SCHEMBL3507605 | 0.70 | GPR139 (0.42) | HDAC1HDAC2HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945609-A2 | AMINO ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007029036-A2 | AMINO ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-03-15 | — | — | WO | disclosed |