Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | NPY4R | P50391 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4607212 | 1.00 | ALDH1A1 (0.40) | ALDH1A1KDM4ESLC6A2FGF23RAB9A | |
| SCHEMBL4608025 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDLMNAMEN1 | |
| SCHEMBL4607515 | 0.75 | SLC6A2 (0.41) | ALDH1A1SLC6A2RAB9AHPGDNPY1R | |
| SCHEMBL7318404 | 0.73 | ALDH1A1 (0.46) | ALDH1A1KDM4ERAB9ALMNAMEN1 | |
| SCHEMBL7318408 | 0.73 | ALDH1A1 (0.46) | ALDH1A1KDM4ERAB9ALMNAMEN1 | |
| SCHEMBL1201854 | 0.73 | ALDH1A1 (0.59) | ALDH1A1KDM4EHPGDLMNAMEN1 | |
| SCHEMBL15874872 | 0.73 | ALDH1A1 (0.59) | ALDH1A1KDM4EHPGDLMNAMEN1 | |
| SCHEMBL1201856 | 0.73 | ALDH1A1 (0.59) | ALDH1A1KDM4EHPGDLMNAMEN1 | |
| SCHEMBL11832797 | 0.72 | KDM4E (0.44) | ALDH1A1KDM4EHPGDLMNAKMT2A | |
| Water SCHEMBL8222140 | 0.71 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |
| EP-1246797-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001042203-A1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |