Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | EEF2K | O00418 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26907022 | 0.83 | PRMT3 (0.48) | CNR2CES2CES1GAANPC1 | |
| Hydrochloric Acid SCHEMBL382716 | 0.81 | GAA (0.43) | CNR2CES2CES1GAAMTNR1A | |
| SCHEMBL14691232 | 0.79 | CFD (0.40) | — | |
| SCHEMBL13997820 | 0.79 | MALT1 (0.45) | GAAMC4R | |
| SCHEMBL20213832 | 0.78 | TAAR1 (0.46) | CES2CES1CYP3A4 | |
| SCHEMBL11495829 | 0.78 | CES2 (0.46) | CNR2CES2CES1GAAEEF2K | |
| SCHEMBL3510106 | 0.78 | MTNR1A (0.53) | CNR2MTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL20580058 | 0.77 | GAA (0.42) | CNR2CES2CES1GAAPRMT3 | |
| SCHEMBL16371920 | 0.77 | CES2 (0.43) | CNR2CES2CES1GAACYP3A4 | |
| SCHEMBL5061358 | 0.76 | POLB (0.43) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |