Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608251 | 0.84 | MITF (0.43) | POLBADRB3CHRNA4MEN1ALDH1A1 | |
| SCHEMBL2990481 | 0.83 | ADRB3 (0.56) | ADRB3ADRB2ADRB1DNM1L3MBTL1 | |
| SCHEMBL4607514 | 0.81 | ADRB3 (0.49) | ADRB3BCHECHRNB2ACHECHRNA7 | |
| SCHEMBL4605555 | 0.76 | ADRB3 (0.49) | ADRB3ADRB2ADRB1DNM1 | |
| SCHEMBL4606756 | 0.76 | ADRB3 (0.47) | ADRB3BCHECHRNB2ACHECHRNA7 | |
| SCHEMBL4607708 | 0.75 | BCHE (0.46) | ADRB3BCHECHRNB2ACHECHRNA7 | |
| SCHEMBL4605132 | 0.74 | ADRB3 (0.46) | ADRB3ADRB2ADRB1DNM1MAPT | |
| SCHEMBL4606968 | 0.73 | ADRB3 (0.42) | ADRB3ADRB2ADRB1DNM1MEN1 | |
| SCHEMBL4696496 | 0.71 | ALDH1A1 (0.41) | POLBADRB3CHRNA4ADRB2ADRB1 | |
| SCHEMBL4607629 | 0.71 | KDM4E (0.52) | MEN1ALDH1A1MAPTKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945612-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | Orchid Research Laboratories Limited (IN) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007042912-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2007-04-19 | — | — | WO | disclosed |