Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 9/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 9/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | TLR4 | O00206 | 2/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4606756 | 0.90 | ADRB3 (0.47) | BCHECHRNB2ACHECHRNA7CHRNA4 | |
| SCHEMBL4607514 | 0.84 | ADRB3 (0.49) | BCHECHRNB2ACHECHRNA7CHRNA4 | |
| SCHEMBL2993358 | 0.83 | ADRB2 (0.65) | BCHECHRNB2ACHECHRNA7CHRNA4 | |
| SCHEMBL4605555 | 0.79 | ADRB3 (0.49) | ADRB3ADRB2ADRB1DNM1DRD1 | |
| SCHEMBL4605132 | 0.77 | ADRB3 (0.46) | ADRB3ADRB2ADRB1KMT2ADRD2 | |
| SCHEMBL4608053 | 0.77 | MAPT (0.50) | ADRB3ADRB2ADRB1KMT2AMEN1 | |
| SCHEMBL4605749 | 0.76 | TLR9 (0.49) | ADRB3ADRB2ADRB1KDM4EGAA | |
| SCHEMBL4607757 | 0.75 | POLB (0.44) | BCHECHRNB2ACHECHRNA7CHRNA4 | |
| SCHEMBL4606968 | 0.74 | ADRB3 (0.42) | ADRB3ADRB2ADRB1KMT2AMEN1 | |
| SCHEMBL2994599 | 0.73 | ADRB2 (0.68) | ADRB3ADRB2ADRB1KMT2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945612-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | Orchid Research Laboratories Limited (IN) | 2008-07-23 | — | — | EP | claimed |
| WO-2007042912-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2007-04-19 | — | — | WO | claimed |
| EP-1945612-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | Orchid Research Laboratories Limited (IN) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007042912-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2007-04-19 | — | — | WO | disclosed |