Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3940682 | 0.78 | BACE1 (0.44) | BACE1 | |
| SCHEMBL1474688 | 0.75 | DUT (0.35) | BACE1 | |
| SCHEMBL29823262 | 0.75 | DUT (0.35) | BACE1 | |
| SCHEMBL8664580 | 0.73 | HRH3 (0.35) | — | |
| SCHEMBL2168948 | 0.73 | — | — | |
| SCHEMBL8069572 | 0.73 | DUT (0.39) | BACE1 | |
| SCHEMBL6702684 | 0.73 | BACE1 (0.41) | BACE1 | |
| SCHEMBL8526099 | 0.70 | CYP1A2 (0.41) | — | |
| SCHEMBL8922566 | 0.70 | CHRNB2 (0.38) | — | |
| SCHEMBL5196496 | 0.70 | AGXT (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945206-A1 | INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS | Athersys, Inc. (US) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007047775-A1 | INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS | ATHERSYS, INC. (US) | 2007-04-26 | — | — | WO | disclosed |