Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA7 | P43166 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.49 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.41 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL462565 | 0.86 | HSP90AA1 (0.70) | HSP90AA1CA12CA1CA2CA7 | |
| SCHEMBL462566 | 0.78 | EGFR (0.47) | EGFRHSP90AA1CA12CA1CA2 | |
| SCHEMBL461117 | 0.74 | HSP90AA1 (0.69) | EGFRHSP90AA1HKDC1NOX4 | |
| SCHEMBL413095 | 0.70 | EGFR (1.00) | EGFRCA12CA1CA2CA7 | |
| SCHEMBL460120 | 0.68 | HSP90AA1 (0.45) | EGFRHSP90AA1CA12CA1CA2 | |
| SCHEMBL4211275 | 0.68 | CA12 (0.70) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3297034 | 0.68 | KDM4C (0.61) | EGFRCA12CA1CA2CA7 | |
| SCHEMBL26983171 | 0.68 | CA12 (1.00) | CA12CA1CA2CA7CA9 | |
| SCHEMBL26104013 | 0.67 | CA12 (0.68) | CA12CA1CA2CA7CA9 | |
| SCHEMBL7514919 | 0.66 | CA12 (0.72) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |