Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.70 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.52 |
| ▸ | CCR6 | P51684 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 6/20 | 0.50 |
| ▸ | CA2 | P00918 | 6/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL460805 | 0.86 | EGFR (0.54) | HSP90AA1HKDC1CCR6CA1CA2 | |
| SCHEMBL462566 | 0.72 | EGFR (0.47) | HSP90AA1CA1CA2CA12CA9 | |
| SCHEMBL11252769 | 0.69 | HKDC1 (0.60) | HSP90AA1HKDC1CA1CA2ALOX5 | |
| SCHEMBL5794016 | 0.69 | HKDC1 (1.00) | HSP90AA1HKDC1CA1CA2ALOX5 | |
| SCHEMBL701832 | 0.68 | CA12 (0.83) | HSP90AA1CA1CA2CA12CA9 | |
| SCHEMBL29020376 | 0.68 | LMNA (0.59) | HSP90AA1CA1CA2CA12CA9 | |
| SCHEMBL411958 | 0.68 | HSP90AA1 (0.53) | HSP90AA1HKDC1CA1CA2CA12 | |
| SCHEMBL28307864 | 0.67 | CA12 (0.63) | HSP90AA1CA1CA2CA12CA9 | |
| SCHEMBL5735863 | 0.67 | CA12 (0.68) | CA1CA2CA12CA9CA7 | |
| SCHEMBL28761675 | 0.66 | CA12 (0.79) | HSP90AA1CA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |