Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4607185 | 0.91 | ADRB3 (0.46) | MAPTHSD17B10POLBADRB1ADRB3 | |
| SCHEMBL4605834 | 0.85 | CYP1A2 (0.44) | MAPTHSD17B10POLBADRB1ADRB3 | |
| SCHEMBL4607632 | 0.85 | MET (0.41) | MAPTHSD17B10POLBADRB1ADRB3 | |
| SCHEMBL4608603 | 0.85 | ADRB3 (0.49) | ADRB1ADRB3ADRB2ALDH1A1 | |
| SCHEMBL4606968 | 0.84 | ADRB3 (0.42) | MAPTHSD17B10ADRB1ADRB3ADRB2 | |
| SCHEMBL3000457 | 0.82 | ADRB1 (0.71) | MAPTHSD17B10POLBADRB1ADRB3 | |
| SCHEMBL4606756 | 0.80 | ADRB3 (0.47) | ADRB1ADRB3ADRB2SIGMAR1KMT2A | |
| SCHEMBL4605749 | 0.78 | TLR9 (0.49) | MAPTPOLBADRB1ADRB3ADRB2 | |
| SCHEMBL4605132 | 0.78 | ADRB3 (0.46) | MAPTADRB1ADRB3ADRB2KMT2A | |
| SCHEMBL4607629 | 0.78 | KDM4E (0.52) | MAPTHSD17B10SMN1; SMN2L3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945612-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | Orchid Research Laboratories Limited (IN) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007042912-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2007-04-19 | — | — | WO | disclosed |