SCHEMBL460806

SCHEMBL460806

CC(C)c1c(NCc2cc(O)c(Br)cc2O)ccc(C(=O)O)c1O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR6 P51684 1/20 0.36
HKDC1 Q2TB90 1/20 0.36
MAPT P10636 3/20 0.36
NOX4 Q9NPH5 2/20 0.36
EGFR P00533 2/20 0.36
RGS12 O14924 1/20 0.36
ALDH1A1 P00352 1/20 0.36
LCK P06239 1/20 0.36
CAMKK2 Q96RR4 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
KDM4C Q9H3R0 4/20 0.34
CISD1 Q9NZ45 2/20 0.33
PIM1 P11309 1/20 0.32
DYRK2 Q92630 1/20 0.32
HSP90AA1 P07900 1/20 0.32
APEX1 P27695 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
ALOX15 P16050 1/20 0.32
ALOX12 P18054 1/20 0.32
SELL P14151 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL462566 0.78 EGFR (0.47) MAPTNOX4EGFRRGS12ALDH1A1
SCHEMBL461118 0.72 EGFR (0.52) HKDC1MAPTNOX4EGFRRGS12
SCHEMBL460805 0.70 EGFR (0.54) CCR6HKDC1NOX4EGFRHSP90AA1
SCHEMBL27124386 0.67 SELL (0.57) MAPTALDH1A1TDP1SMN1; SMN2ALOX15
SCHEMBL413096 0.67 EGFR (0.58) HKDC1MAPTNOX4EGFRRGS12
SCHEMBL462565 0.67 HSP90AA1 (0.70) CCR6HKDC1MAPTALDH1A1HSP90AA1
SCHEMBL1583816 0.66 GRM1 (0.49) MAPTALDH1A1TDP1SELLSELP
SCHEMBL31044053 0.65 GRM1 (0.47) MAPTALDH1A1TDP1SELLSELP
SCHEMBL6094207 0.62 ALDH1A1 (0.51) MAPTNOX4EGFRRGS12ALDH1A1
SCHEMBL39247 0.61 SELL (0.57) MAPTALDH1A1TDP1SMN1; SMN2ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120021519-A1 EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) 2012-01-26 US disclosed