Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | APP | P05067 | 3/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608144 | 0.83 | SLC9A1 (0.50) | KDM1ANR3C2SLC9A1SLC6A2SLC6A4 | |
| SCHEMBL4607106 | 0.81 | SLC6A4 (0.43) | KDM1ADPP4NR3C2SLC9A1SLC6A2 | |
| SCHEMBL4606753 | 0.80 | KDM1A (0.42) | KDM1AMAOAMAOBCYP3A4CYP2C9 | |
| SCHEMBL4607507 | 0.78 | OPRL1 (0.44) | HTT | |
| SCHEMBL4608450 | 0.76 | GRIA4 (0.46) | KDM1AMAOAMAOBNR3C2SLC9A1 | |
| SCHEMBL4607572 | 0.75 | GRIA4 (0.47) | — | |
| SCHEMBL4606553 | 0.75 | SLC6A2 (0.61) | KDM1AMAOBLMNASLC9A1SLC6A2 | |
| SCHEMBL4608244 | 0.73 | SIRT2 (0.40) | NR3C2SLC9A1SLC6A2SLC6A4 | |
| SCHEMBL4606578 | 0.72 | HSD17B1 (0.51) | MAOAMAOBHSD17B10SLC6A2SLC6A4 | |
| SCHEMBL4608166 | 0.72 | SLC6A2 (0.42) | MAOBKDM4EALDH1A1KMT2ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | claimed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | claimed |
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |