Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608144 | 0.85 | SLC9A1 (0.50) | SLC6A4SLC6A2NR3C2SIRT2SIRT1 | |
| SCHEMBL4606553 | 0.82 | SLC6A2 (0.61) | SLC6A4SLC6A2SLC9A1KDM1ADGAT1 | |
| SCHEMBL4606744 | 0.81 | KDM1A (0.43) | SLC6A4SLC6A2NR3C2SLC9A1KDM1A | |
| SCHEMBL4608450 | 0.78 | GRIA4 (0.46) | NR3C2SIRT2SIRT1SLC9A1KDM1A | |
| SCHEMBL4607109 | 0.77 | KDM1A (0.43) | SLC6A4KDM1ASLC6A3 | |
| SCHEMBL4607726 | 0.77 | HRH3 (0.46) | SLC6A4SLC6A2KDM1AHRH3DGAT1 | |
| SCHEMBL4604971 | 0.77 | SLC6A2 (0.52) | SLC6A4SLC6A2PARP1KDM1A | |
| SCHEMBL4608225 | 0.77 | SCN9A (0.44) | SLC6A4SLC6A2KDM1ADGAT1 | |
| SCHEMBL4608244 | 0.77 | SIRT2 (0.40) | SLC6A4SLC6A2NR3C2SIRT2SIRT1 | |
| SCHEMBL4607572 | 0.77 | GRIA4 (0.47) | SIRT2SIRT1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | claimed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | claimed |
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |
| US-6639107-B1 | Potentiating glutamate receptor function | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |