Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3354917 | 0.77 | HSD17B10 (0.48) | ALDH1A1HSD17B10POLBTDP1KMT2A | |
| SCHEMBL11565380 | 0.77 | HSD17B10 (0.52) | ALDH1A1HSD17B10POLBTDP1KMT2A | |
| SCHEMBL28328527 | 0.75 | ALDH1A1 (0.43) | ALDH1A1HSD17B10POLBKMT2AMEN1 | |
| SCHEMBL29190567 | 0.74 | ACHE (0.42) | ALDH1A1HSD17B10POLBTDP1KMT2A | |
| SCHEMBL31720579 | 0.74 | ACHE (0.46) | ALDH1A1HSD17B10POLBTDP1KMT2A | |
| SCHEMBL8066554 | 0.74 | HSD17B10 (0.45) | ALDH1A1HSD17B10POLBTDP1KMT2A | |
| SCHEMBL29669355 | 0.74 | HSD17B10 (0.50) | ALDH1A1HSD17B10POLBTDP1KMT2A | |
| SCHEMBL28193317 | 0.74 | HSD17B10 (0.45) | ALDH1A1HSD17B10POLBTDP1KMT2A | |
| SCHEMBL30936695 | 0.73 | LMNA (0.49) | ALDH1A1HSD17B10POLBTDP1KMT2A | |
| SCHEMBL15054133 | 0.73 | ALDH1A1 (0.41) | ALDH1A1POLBTDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595482-A1 | ALDOSTERONE SYNTHASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |