Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 6/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.41 |
| ▸ | ACP3 | P15309 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651107 | 0.87 | MAOB (0.44) | MAOBKIF11PSEN1PSEN2APH1B | |
| SCHEMBL14513508 | 0.82 | MAOB (0.52) | MAOBKIF11PSEN1PSEN2APH1B | |
| SCHEMBL4608415 | 0.79 | ALDH1A1 (0.41) | ALDH1A1FDFT1 | |
| SCHEMBL2654304 | 0.79 | RXRA (0.47) | KIF11PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13003550 | 0.78 | ALDH1A1 (0.46) | MAOBALDH1A1HTR2AHTR2CHTR2B | |
| SCHEMBL444104 | 0.78 | TSHR (0.55) | TRPA1 | |
| SCHEMBL8283173 | 0.78 | TRPA1 (0.52) | ALDH1A1ACP3TRPA1 | |
| SCHEMBL8323180 | 0.78 | TSHR (0.55) | TRPA1 | |
| SCHEMBL8967452 | 0.78 | TSHR (0.55) | TRPA1 | |
| SCHEMBL16379332 | 0.77 | TMEM97 (0.50) | MAOBALDH1A1FDFT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |