Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8724217 | 0.92 | NR1H2 (0.39) | L3MBTL1ALDH1A1LMNAKMT2ATDP1 | |
| SCHEMBL15723420 | 0.80 | SRC (0.36) | ESR1ESR2L3MBTL1ALDH1A1 | |
| SCHEMBL20556352 | 0.80 | SRC (0.36) | ESR1ESR2L3MBTL1ALDH1A1 | |
| SCHEMBL20917440 | 0.77 | CTSK (0.41) | L3MBTL1LMNANR1H2NR1H3 | |
| SCHEMBL642839 | 0.77 | SMN1; SMN2 (0.41) | ALDH1A1LMNAKMT2ATDP1TP53 | |
| SCHEMBL9382586 | 0.77 | SMN1; SMN2 (0.41) | ALDH1A1LMNAKMT2ATDP1TP53 | |
| SCHEMBL6257491 | 0.77 | SMN1; SMN2 (0.38) | L3MBTL1ALDH1A1LMNAKMT2ATDP1 | |
| SCHEMBL6257488 | 0.77 | SMN1; SMN2 (0.38) | L3MBTL1ALDH1A1LMNAKMT2ATDP1 | |
| SCHEMBL9407522 | 0.75 | SMN1; SMN2 (0.42) | L3MBTL1ALDH1A1LMNAKMT2ATDP1 | |
| SCHEMBL994016 | 0.74 | MMP13 (0.41) | L3MBTL1GAANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907352-A2 | NOVEL DERIVATIVES OF AMINO ACIDS FOR TREATMENT OF OBESITY AND RELATED DISORDERS | Bexel Pharmaceuticals Inc (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007005774-A2 | NOVEL DERIVATIVES OF AMINO ACIDS FOR TREATMENT OF OBESITY AND RELATED DISORDERS | BEXEL PHARMACEUTICALS, INC. (US) | 2007-01-11 | — | — | WO | disclosed |