Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 11/20 | 1.00 |
| ▸ | ABCC8 | Q09428 | 11/20 | 1.00 |
| ▸ | KCNJ11 | Q14654 | 11/20 | 1.00 |
| ▸ | KCNJ8 | Q15842 | 11/20 | 1.00 |
| ▸ | PDK1 | Q15118 | 11/20 | 0.76 |
| ▸ | PDK2 | Q15119 | 11/20 | 0.76 |
| ▸ | PDK3 | Q15120 | 11/20 | 0.76 |
| ▸ | PDK4 | Q16654 | 11/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5549859 | 1.00 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL4608131 | 0.87 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL4608961 | 0.87 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL4608956 | 0.86 | PDK1 (1.00) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL4623429 | 0.86 | ABCC9 (0.76) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL4609103 | 0.84 | ABCC9 (0.73) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL4607928 | 0.84 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL4610616 | 0.83 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5669686 | 0.82 | ABCC9 (0.67) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| Zd-6169 SCHEMBL2123811 | 0.81 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070203225-A1 | METHOD OF INCREASING ENDOGENOUS ADIPONECTIN PRODUCTION AND LEPTIN PRODUCTION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-08-30 | — | — | US | claimed |
| EP-1730310-A2 | A FORMULATION FOR INCREASING ENDOGENOUS ADIPONECTIN AND LEPTIN PRODUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-12-13 | — | — | EP | claimed |
| US-20050261362-A1 | Method of increasing endogenous adiponectin and leptin production | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2005-11-24 | — | — | US | claimed |
| WO-2005092040-A2 | A FORMULATION FOR INCREASING ENDOGENOUS ADIPONECTIN AND LEPTIN PRODUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-10-06 | — | — | WO | claimed |
| JP-2002505293-A | — | — | 2002-02-19 | — | — | JP | claimed |
| EP-0617010-B1 | Therapeutic compounds | ASTRAZENECA AB (SE) | 2002-01-09 | — | — | EP | claimed |
| EP-1059927-A1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | AstraZeneca AB (SE) | 2000-12-20 | — | — | EP | claimed |
| WO-1999044618-A1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 1999-09-10 | — | — | WO | claimed |
| US-5900432-A | Therapeutic N-(4-benzoyl-2-methyl-phenyl)-3,3,3-trifluoro-2-hydroxy-2-methyl-propanamides | ZENECA LIMITED (GB) | 1999-05-04 | — | — | US | claimed |
| EP-0617010-A1 | Therapeutic compounds | ZENECA LIMITED (GB) | 1994-09-28 | — | — | EP | claimed |
| JP-6321879-A | — | — | None | — | — | JP | disclosed |
| EP-1059927-B1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | disclosed |
| US-20070203225-A1 | METHOD OF INCREASING ENDOGENOUS ADIPONECTIN PRODUCTION AND LEPTIN PRODUCTION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
| EP-1730310-A2 | A FORMULATION FOR INCREASING ENDOGENOUS ADIPONECTIN AND LEPTIN PRODUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-12-13 | — | — | EP | disclosed |
| US-20050261362-A1 | Method of increasing endogenous adiponectin and leptin production | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2005-11-24 | — | — | US | disclosed |
| US-5900432-A | Therapeutic N-(4-benzoyl-2-methyl-phenyl)-3,3,3-trifluoro-2-hydroxy-2-methyl-propanamides | ZENECA LIMITED (GB) | 1999-05-04 | — | — | US | disclosed |
| US-5900432-A | Therapeutic N-(4-benzoyl-2-methyl-phenyl)-3,3,3-trifluoro-2-hydroxy-2-methyl-propanamides | ZENECA LIMITED (GB) | 1999-05-04 | — | — | US | disclosed |
| US-5482969-A | Certain N(4-benzoyl-2-phenyl)-3- trifluoro-2-hydroxy-propanamide derivatives | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| JP-H06321879-A | THERAPEUTIC COMPOUND | ZENECA LTD | 1994-11-22 | — | — | JP | disclosed |
| EP-0617010-A1 | Therapeutic compounds | ZENECA LIMITED (GB) | 1994-09-28 | — | — | EP | disclosed |