Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4609928 | 0.81 | TSHR (0.48) | TSHRGRM5LMNASMN1; SMN2MAPK1 | |
| SCHEMBL27736439 | 0.74 | TSHR (0.59) | TSHRGRM5LMNASMN1; SMN2MAPK1 | |
| SCHEMBL4713865 | 0.73 | GRM5 (0.52) | TSHRGRM5LMNASMN1; SMN2TP53 | |
| SCHEMBL9261218 | 0.69 | ADRA2A (0.40) | TSHRLMNADRD4GFERDRD2 | |
| SCHEMBL27757105 | 0.67 | GRM5 (0.56) | TSHRGRM5LMNASMN1; SMN2TP53 | |
| SCHEMBL27736436 | 0.66 | TSHR (0.62) | TSHRGRM5LMNASMN1; SMN2MAPK1 | |
| SCHEMBL5722475 | 0.65 | PKM (0.46) | TSHRLMNASMN1; SMN2GFERMAPT | |
| SCHEMBL6027334 | 0.65 | SLC1A3 (0.49) | TSHRMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL28074621 | 0.65 | GRM5 (0.47) | TSHRGRM5LMNASMN1; SMN2DRD4 | |
| SCHEMBL10151396 | 0.65 | DRD4 (0.55) | TSHRGRM5LMNADRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021015-A2 | GHRELIN/GROWTH HORMONE RELEASING PEPTIDE/GROWTH HORMONE SECRETATOGUE RECEPTOR ANTAGONISTS AND USES THEREOF | The Administrators Of The Tulane Educational Fund (US) | 2009-02-11 | — | — | EP | claimed |
| WO-2007127457-A2 | GHRELIN/GROWTH HORMONE RELEASING PEPTIDE/GROWTH HORMONE SECRETATOGUE RECEPTOR ANTAGONISTS AND USES THEREOF | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2007-11-08 | — | — | WO | claimed |