Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 17/20 | 0.43 |
| ▸ | CCR4 | P51679 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5573793 | 0.87 | SMN1; SMN2 (0.44) | CCR5CCR4KCNH2HDAC1HDAC6 | |
| SCHEMBL5576527 | 0.85 | DRD2 (0.41) | CCR5CCR4KCNH2HDAC1HDAC6 | |
| SCHEMBL4597857 | 0.78 | CCR5 (0.57) | CCR5CCR4KCNH2 | |
| SCHEMBL5575918 | 0.76 | CCR5 (0.77) | CCR5CCR4KCNH2 | |
| SCHEMBL4597655 | 0.75 | CCR5 (0.43) | CCR5CCR4KCNH2HDAC1HDAC6 | |
| SCHEMBL5575518 | 0.72 | CCR5 (0.66) | CCR5CCR4KCNH2 | |
| SCHEMBL4607778 | 0.71 | DRD2 (0.44) | CCR5CCR4KCNH2HDAC1HDAC6 | |
| SCHEMBL4595920 | 0.71 | STS (0.44) | CCR5HDAC1HDAC6KMT2A | |
| SCHEMBL5576431 | 0.70 | CCR5 (0.65) | CCR5CCR4KCNH2 | |
| SCHEMBL4598523 | 0.68 | CCR5 (0.60) | CCR5CCR4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |