Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.38 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | TPH1 | P17752 | 1/20 | 0.37 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL5358311 | 1.00 | ITGB3 (0.52) | ITGB3ITGA2BTHRBGSRPTPN1 | |
| Lysine SCHEMBL4198912 | 0.93 | ITGB3 (0.53) | ITGB3ITGA2BTHRBGSRPTPN1 | |
| Glutamic Acid SCHEMBL1696963 | 0.88 | ITGB3 (0.57) | ITGB3ITGA2BTHRBGSRPTPN1 | |
| Lysine SCHEMBL1921517 | 0.88 | ITGB3 (0.60) | ITGB3ITGA2BTHRBGSRPTPN1 | |
| SCHEMBL571283 | 0.88 | ITGB3 (0.65) | ITGB3ITGA2BTHRBGSRPTPN1 | |
| Lysine SCHEMBL3497594 | 0.87 | ITGB3 (0.54) | ITGB3ITGA2BTHRBGSRPTPN1 | |
| Lysine SCHEMBL1921682 | 0.87 | ITGB3 (0.54) | ITGB3ITGA2BTHRBGSRPTPN1 | |
| SCHEMBL16972711 | 0.87 | SLC7A5 (0.50) | ITGB3ITGA2BPTPN1ALOX15BLM | |
| SCHEMBL1537414 | 0.87 | SLC7A5 (0.50) | ITGB3ITGA2BPTPN1ALOX15BLM | |
| Tyrosine SCHEMBL5358316 | 0.86 | SLC7A5 (0.56) | ITGB3ITGA2BTHRBGSRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1498476-B1 | MUTATED ALKALINE CELLULASE | KAO CORP (JP) | 2008-10-15 | — | — | EP | claimed |
| US-7364891-B2 | Mutated alkaline cellulase | KAO CORPORATION (JP) | 2008-04-29 | — | — | US | claimed |
| EP-1498476-B1 | MUTATED ALKALINE CELLULASE | KAO CORP (JP) | 2008-10-15 | — | — | EP | disclosed |
| US-7364891-B2 | Mutated alkaline cellulase | KAO CORPORATION (JP) | 2008-04-29 | — | — | US | disclosed |
| US-20050287656-A1 | Mutated alkaline cellulase | KAO CORPORATION (JP) | 2005-12-29 | — | — | US | disclosed |
| EP-1498476-A1 | MUTATED ALKALINE CELLULASE | Kao Corporation (JP) | 2005-01-19 | — | — | EP | disclosed |