Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.35 |
| ▸ | CA1 | P00915 | 6/20 | 0.35 |
| ▸ | CA7 | P43166 | 6/20 | 0.35 |
| ▸ | CA9 | Q16790 | 5/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | CA3 | P07451 | 3/20 | 0.33 |
| ▸ | CA4 | P22748 | 3/20 | 0.33 |
| ▸ | CA6 | P23280 | 3/20 | 0.33 |
| ▸ | CA5A | P35218 | 3/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL115429 | 0.82 | NPC1 (0.34) | MEN1KMT2APOLBSMN1; SMN2LMNA | |
| SCHEMBL4838387 | 0.71 | HTR2A (0.36) | MEN1KMT2APOLBSMN1; SMN2HTR2A | |
| SCHEMBL1375450 | 0.71 | NPC1 (0.35) | MEN1KMT2APOLBSMN1; SMN2HTR2A | |
| SCHEMBL374979 | 0.69 | ALDH1A1 (0.33) | MEN1KMT2APOLBSMN1; SMN2HTR2A | |
| SCHEMBL3266678 | 0.68 | MEN1 (0.41) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2073990 | 0.67 | HTR2A (0.36) | MEN1KMT2APOLBSMN1; SMN2HTR2A | |
| SCHEMBL553792 | 0.67 | NPC1 (0.35) | MEN1KMT2APOLBSMN1; SMN2HTR2A | |
| SCHEMBL15010759 | 0.67 | POLB (0.33) | MEN1KMT2APOLBSMN1; SMN2HTR2A | |
| SCHEMBL1198917 | 0.67 | ALDH1A1 (0.36) | MEN1KMT2ASMN1; SMN2LMNAHTR2A | |
| SCHEMBL6615965 | 0.67 | NPC1 (0.33) | POLBSMN1; SMN2HTR2ANPC1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140275165-A1 | COMPOUNDS THAT INHIBIT NFkB AND BACE1 ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-09-18 | — | — | US | disclosed |
| US-20120064099-A1 | COMPOUNDS THAT INHIBIT NFKB AND BACE1 ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275165-A1 | COMPOUNDS THAT INHIBIT NFkB AND BACE1 ACTIVITY | NFKBIA, BACE1, BACE2 | CA2 3670/4885CA1 2743/4885CA7 4039/4885 |
| US-20120064099-A1 | COMPOUNDS THAT INHIBIT NFKB AND BACE1 ACTIVITY | NFKBIA, BACE1, BACE2 | CA2 3670/4885CA1 2743/4885CA7 4039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.