Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460447 | 0.77 | S100B (0.36) | KMT2AMEN1MAPTLMNATP53 | |
| SCHEMBL4613489 | 0.76 | ADORA2A (0.44) | CHEK2LOXL2HDAC2HSP90AA1CASP6 | |
| SCHEMBL7800733 | 0.76 | CYP2A6 (0.40) | KMT2AMEN1MAPTLMNATP53 | |
| SCHEMBL7461570 | 0.76 | KMT2A (0.32) | KMT2AMEN1MAPTLMNATP53 | |
| SCHEMBL7807514 | 0.75 | NPC1 (0.41) | HDAC2KMT2AMEN1MAPTADORA2A | |
| SCHEMBL7459856 | 0.75 | S100B (0.35) | KMT2AMEN1MAPTLMNATP53 | |
| SCHEMBL7812166 | 0.75 | KMT2A (0.32) | KMT2AMEN1MAPTLMNATP53 | |
| SCHEMBL7460055 | 0.75 | MAPT (0.34) | KMT2AMEN1MAPTLMNATP53 | |
| SCHEMBL7812328 | 0.74 | S100B (0.31) | KMT2AMEN1MAPTLMNATP53 | |
| SCHEMBL7808530 | 0.74 | S100B (0.34) | KMT2AMEN1MAPTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351945-B1 | NOVEL 1,4-DIAMINO-2-(THIAZOL-2-YL)BENZENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS | WELLA AG (DE) | 2008-01-23 | — | — | EP | disclosed |
| US-6875873-B2 | 1,4-Diamino-2-(thiazol-2-yl)benzene derivatives, and dyes containing said compounds | WELLA AKTIENGESELLSCHAFT (DE) | 2005-04-05 | — | — | US | disclosed |
| EP-1351945-A1 | NOVEL 1,4-DIAMINO-2-(THIAZOL-2-YL)BENZENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS | Wella Aktiengesellschaft (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-20030115683-A1 | Novel 1,4-diamino-2-(thiazol-2-yl)benzene derivatives and dyes containing said compounds | HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) | 2003-06-26 | — | — | US | disclosed |
| WO-2002057243-A1 | NOVEL 1,4-DIAMINO-2-(THIAZOL-2-YL)BENZENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS | WELLA AKTIENGESELLSCHAFT (DE) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030115683-A1 | Novel 1,4-diamino-2-(thiazol-2-yl)benzene derivatives and dyes containing said compounds | KRT18, DSP, TUBB1 | CHEK2 306/4885LOXL2 805/4885HDAC2 1657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.