Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 4/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4613518 | 0.79 | ADRB2 (0.40) | ADORA2AADORA1HDAC2CHEK2LOXL2 | |
| SCHEMBL4614878 | 0.76 | CHEK2 (0.36) | ADORA2AADORA1CASP6HDAC2CHEK2 | |
| SCHEMBL7805911 | 0.75 | ADORA1 (0.43) | ADORA2AADORA1HDAC2HDAC3HDAC4 | |
| SCHEMBL11896552 | 0.73 | GCK (0.50) | HDAC2LOXL2GCKHSP90AA1CYP1A1 | |
| SCHEMBL6570757 | 0.73 | FCGR3B (0.39) | CASP6CYP2D6ALDH1A1GAA | |
| SCHEMBL996582 | 0.73 | F2RL1 (0.49) | ADORA2AADORA1CASP6HDAC2CHEK2 | |
| SCHEMBL457582 | 0.73 | HSP90AA1 (0.43) | ADORA2AADORA1HDAC2CHEK2LOXL2 | |
| SCHEMBL7466260 | 0.72 | EEF2K (0.42) | HDAC2CHEK2HDAC1HDAC6CHEK1 | |
| Hydrochloric Acid SCHEMBL10517968 | 0.72 | F2RL1 (0.48) | ADORA2AADORA1CASP6HDAC2CHEK2 | |
| SCHEMBL6572467 | 0.72 | ALDH1A1 (0.37) | CASP6HSP90AA1CYP2D6NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351945-B1 | NOVEL 1,4-DIAMINO-2-(THIAZOL-2-YL)BENZENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS | WELLA AG (DE) | 2008-01-23 | — | — | EP | disclosed |
| WO-2005065686-A1 | DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR | ADIPOGEN PHARMACEUTICALS PTY LIMITED (AU) | 2005-07-21 | — | — | WO | disclosed |
| US-6875873-B2 | 1,4-Diamino-2-(thiazol-2-yl)benzene derivatives, and dyes containing said compounds | WELLA AKTIENGESELLSCHAFT (DE) | 2005-04-05 | — | — | US | disclosed |
| EP-1351945-A1 | NOVEL 1,4-DIAMINO-2-(THIAZOL-2-YL)BENZENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS | Wella Aktiengesellschaft (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-20030115683-A1 | Novel 1,4-diamino-2-(thiazol-2-yl)benzene derivatives and dyes containing said compounds | HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) | 2003-06-26 | — | — | US | disclosed |
| WO-2002057243-A1 | NOVEL 1,4-DIAMINO-2-(THIAZOL-2-YL)BENZENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS | WELLA AKTIENGESELLSCHAFT (DE) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030115683-A1 | Novel 1,4-diamino-2-(thiazol-2-yl)benzene derivatives and dyes containing said compounds | KRT18, DSP, TUBB1 | ADORA2A 4262/4885ADORA1 3505/4885CASP6 678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.