Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.57 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.54 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | FASN | P49327 | 4/20 | 0.48 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6139577 | 0.93 | ALDH1A1 (0.68) | ALDH1A1HPGDKDM4EPOLBALOX15 | |
| SCHEMBL4618663 | 0.88 | ALDH1A1 (0.78) | ALDH1A1HPGDKDM4EPOLBALOX15 | |
| Trifluoroacetic Acid SCHEMBL6824444 | 0.87 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4EPOLBALOX15 | |
| SCHEMBL6821107 | 0.82 | ALDH1A1 (0.67) | ALDH1A1HPGDKDM4EPOLBALOX15 | |
| SCHEMBL4617450 | 0.81 | PROKR1 (0.59) | ALDH1A1HPGDPOLBL3MBTL3L3MBTL1 | |
| SCHEMBL14085084 | 0.81 | ALDH1A1 (0.65) | ALDH1A1HPGDKDM4EPOLBALOX15 | |
| SCHEMBL13779979 | 0.81 | POLB (0.65) | ALDH1A1HPGDKDM4EPOLBALOX15 | |
| SCHEMBL601333 | 0.80 | HRH3 (0.54) | ALDH1A1KDM4EUBE2TSMN1; SMN2 | |
| SCHEMBL6140027 | 0.80 | HRH3 (0.58) | ALDH1A1KDM4EUBE2T | |
| SCHEMBL13648899 | 0.80 | ALDH1A1 (0.64) | ALDH1A1HPGDKDM4EPOLBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | ALDH1A1 1865/4885HPGD 2925/4885KDM4E 3044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.