Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12500983 | 0.71 | DAO (0.38) | MAPTKDM4E | |
| SCHEMBL1594455 | 0.71 | TNKS2 (0.35) | TNKS2SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL8558204 | 0.71 | MAPT (0.41) | TNKS2KMT2AMEN1MAPTLMNA | |
| SCHEMBL6256546 | 0.69 | ALDH1A1 (0.31) | KMT2AMEN1MAPTALDH1A1HPGD | |
| SCHEMBL19606308 | 0.68 | BRD4 (0.36) | SMN1; SMN2KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL28967201 | 0.65 | DAO (0.35) | KMT2AMEN1ALDH1A1ADORA3 | |
| SCHEMBL22686800 | 0.65 | SMN1; SMN2 (0.37) | TNKS2SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL15669988 | 0.64 | SMN1; SMN2 (0.54) | TNKS2SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL23895438 | 0.63 | ALDH1A1 (0.44) | KMT2AMEN1MAPTCYP1A2CYP3A4 | |
| SCHEMBL17642195 | 0.63 | ALDH1A1 (0.37) | ALDH1A1HPGDRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879885-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F. Hoffmann-Roche AG (CH) | 2008-01-23 | — | — | EP | claimed |
| WO-2006117306-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-09 | — | — | WO | claimed |
| US-11975032-B2 | Medicament for liver regeneration and for treatment of liver failure | MEDIZINISCHE HOCHSCHULE HANNOVER (DE) | 2024-05-07 | — | — | US | disclosed |
| US-6936633-B2 | Pyrrolidinone derivatives | UCB S.A. (BE) | 2005-08-30 | — | — | US | disclosed |
| US-20050004180-A1 | Pyrrolidinone derivatives | USB S.A. (BE) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11975032-B2 | Medicament for liver regeneration and for treatment of liver failure | PYGL, HNF4A, ATF1 | TNKS2 3851/4885SMN1; SMN2 3176/4885KMT2A 2105/4885 |
| US-20050004180-A1 | Pyrrolidinone derivatives | CCR2, CCR1, CCL2 | TNKS2 2264/4885SMN1; SMN2 4049/4885KMT2A 3360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.