Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9068972 | 0.79 | HTT (0.41) | CYP2D6ADRA2AADRA1AMEN1KMT2A | |
| SCHEMBL19122094 | 0.78 | POLB (0.43) | CYP2D6ADRA2AADRA1AMEN1KMT2A | |
| SCHEMBL4711687 | 0.75 | CYP2D6 (0.37) | CYP2D6ADRA2AADRA1AMEN1KMT2A | |
| SCHEMBL1133802 | 0.73 | ALDH1A1 (0.44) | CYP2D6MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL862161 | 0.71 | ALDH1A1 (0.56) | MEN1KMT2AMAPK1ALDH1A1CYP3A4 | |
| SCHEMBL8716433 | 0.69 | RAB9A (0.46) | CYP2D6MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL385533 | 0.69 | — | — | |
| SCHEMBL7399351 | 0.68 | ESR1 (0.40) | KMT2AALDH1A1 | |
| SCHEMBL8066434 | 0.66 | ALDH1A1 (0.44) | CYP2D6MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL12141429 | 0.65 | ALDH1A1 (0.48) | MEN1KMT2AMAPK1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081893-A1 | INTRACELLULAR TARGETING OF OLIGONUCLEOTIDES | ENTRADA THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| EP-1891090-A2 | MACROCYCLIC GHRELIN RECEPTOR ANTAGONISTS AND INVERSE AGONISTS AND METHODS OF USING THE SAME | Tranzyme Pharma, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006137974-A2 | MACROCYCLIC GHRELIN RECEPTOR ANTAGONISTS AND INVERSE AGONISTS AND METHODS OF USING THE SAME | TRANZYME PHARMA, INC. (US) | 2006-12-28 | — | — | WO | disclosed |
| EP-0707564-A1 | DIFLUORO STATONE ANALOGS | MERRELL PHARMACEUTICALS INC. (US) | 1996-04-24 | — | — | EP | disclosed |