Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618568 | 0.89 | L3MBTL1 (0.53) | L3MBTL1TSHRLMNAALDH1A1USP2 | |
| SCHEMBL4618430 | 0.88 | SFRP1 (0.54) | L3MBTL1LMNAALDH1A1GAAHTT | |
| SCHEMBL4617217 | 0.81 | SFRP1 (0.47) | L3MBTL1ALDH1A1GAASFRP1TP53 | |
| SCHEMBL4617064 | 0.81 | SFRP1 (0.61) | L3MBTL1LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4618044 | 0.81 | ADRB3 (0.50) | ALDH1A1GAAHTTSMN1; SMN2NAMPT | |
| SCHEMBL4618668 | 0.80 | ADRB3 (0.48) | L3MBTL1ALDH1A1NAMPTTBXAS1ADRB2 | |
| SCHEMBL4617909 | 0.80 | SFRP1 (0.52) | TBXAS1SFRP1ADRB2ADRB1ADRB3 | |
| SCHEMBL6102785 | 0.79 | SFRP1 (0.56) | L3MBTL1LMNAALDH1A1SMN1; SMN2SFRP1 | |
| SCHEMBL6103706 | 0.79 | SFRP1 (0.56) | L3MBTL1LMNAALDH1A1SMN1; SMN2SFRP1 | |
| SCHEMBL4637256 | 0.76 | SFRP1 (0.52) | L3MBTL1ALDH1A1SFRP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | claimed |
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | L3MBTL1 4156/4885TSHR 3611/4885LMNA 4608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.