Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | BCL9 | O00512 | 1/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 2/20 | 0.31 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4617631 | 0.88 | BCL9 (0.44) | HTR7OPRD1RAB9ASLC6A2SLC6A3 | |
| SCHEMBL3135615 | 0.84 | ESR1 (0.39) | OPRD1NPC1RAB9ASLC6A2SLC6A3 | |
| SCHEMBL3562321 | 0.77 | SMN1; SMN2 (0.46) | OPRD1 | |
| SCHEMBL3087766 | 0.77 | HRH2 (0.44) | MAOBL3MBTL1 | |
| SCHEMBL3135618 | 0.77 | ESR1 (0.54) | OPRD1SLC6A2SLC6A3MAOBESR1 | |
| SCHEMBL3069744 | 0.76 | LMNA (0.42) | MAOBGAAL3MBTL1 | |
| SCHEMBL3075680 | 0.76 | LTA4H (0.46) | PLA2G7L3MBTL1 | |
| SCHEMBL3074106 | 0.75 | BCL2L1 (0.49) | HTR7OPRD1ESR1RXRATSHR | |
| SCHEMBL4728801 | 0.74 | FFAR4 (0.34) | OPRD1SLC6A2SLC6A3PLA2G7CYP2C9 | |
| SCHEMBL3082749 | 0.73 | NR1I2 (0.43) | MAOBESR1PLA2G7GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891026-A2 | CYCLOALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | Smithkline Beecham Corporation (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006127871-A2 | CYCLOALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-30 | — | — | WO | disclosed |