Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | GCG | P01275 | 3/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.31 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.31 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3562321 | 0.83 | SMN1; SMN2 (0.46) | MAPTTP53SMN1; SMN2OPRD1PPARG | |
| SCHEMBL3075680 | 0.79 | LTA4H (0.46) | FFAR4SMN1; SMN2PPARGPPARAPLA2G7 | |
| SCHEMBL3069744 | 0.78 | LMNA (0.42) | TP53SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL4728795 | 0.77 | PPARA (0.40) | SMN1; SMN2PPARGPPARAALDH1A1PLA2G7 | |
| SCHEMBL4617631 | 0.76 | BCL9 (0.44) | MAPTSMN1; SMN2OPRD1SLC6A2SLC6A3 | |
| SCHEMBL3074106 | 0.74 | BCL2L1 (0.49) | TP53SMN1; SMN2OPRD1ALDH1A1 | |
| SCHEMBL4617633 | 0.74 | HTR7 (0.35) | OPRD1SLC6A2SLC6A3CYP2C9PLA2G7 | |
| SCHEMBL3135618 | 0.74 | ESR1 (0.54) | MAPTOPRD1SLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL3467780 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2OPRD1PPARGPPARAALDH1A1 | |
| SCHEMBL3135615 | 0.72 | ESR1 (0.39) | MAPTSMN1; SMN2OPRD1SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891026-A2 | CYCLOALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | Smithkline Beecham Corporation (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006127871-A2 | CYCLOALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-30 | — | — | WO | disclosed |