Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL9 | O00512 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.37 |
| ▸ | ESR1 | P03372 | 5/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4617633 | 0.88 | HTR7 (0.35) | BCL9CTNNB1ESR1HTR7SLC6A2 | |
| SCHEMBL3135618 | 0.84 | ESR1 (0.54) | KMT2AESR1PGRCHRM2ADORA3 | |
| SCHEMBL3087766 | 0.79 | HRH2 (0.44) | SMN1; SMN2MAPT | |
| SCHEMBL3127812 | 0.79 | BCL9 (0.60) | BCL9CTNNB1SMN1; SMN2KMT2AESR1 | |
| SCHEMBL3069744 | 0.78 | LMNA (0.42) | SMN1; SMN2ALDH1A1HSD17B10KDM4EGLA | |
| SCHEMBL3075680 | 0.78 | LTA4H (0.46) | SMN1; SMN2KDM4E | |
| SCHEMBL8384348 | 0.78 | ELANE (0.55) | BCL9CTNNB1SMN1; SMN2KMT2AESR1 | |
| SCHEMBL3562321 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2OPRD1MAPT | |
| SCHEMBL3135615 | 0.77 | ESR1 (0.39) | SMN1; SMN2KMT2AESR1PGRCHRM2 | |
| SCHEMBL3074106 | 0.76 | BCL2L1 (0.49) | SMN1; SMN2ESR1HTR7ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891026-A2 | CYCLOALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | Smithkline Beecham Corporation (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006127871-A2 | CYCLOALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-30 | — | — | WO | disclosed |