Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.71 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5140 | 0.83 | ENPP2 (1.00) | ENPP2CA1CA2ACHECES2 | |
| SCHEMBL7344145 | 0.83 | ENPP2 (1.00) | ENPP2CA1CA2ACHECES2 | |
| Methyl Alcohol SCHEMBL28712606 | 0.82 | ENPP2 (0.96) | ENPP2CA1CA2ACHECES2 | |
| SCHEMBL12524808 | 0.82 | ENPP2 (0.74) | ENPP2CA1CA2ACHECES2 | |
| SCHEMBL21658445 | 0.79 | ENPP2 (0.69) | ENPP2CA1CA2ACHECES2 | |
| SCHEMBL3737373 | 0.79 | CA1 (0.67) | ENPP2CA1CA2ACHECES2 | |
| 1,3-Dimethoxybenzene SCHEMBL4624082 | 0.78 | ENPP2 (0.68) | ENPP2CA1CA2ACHECES2 | |
| SCHEMBL480132 | 0.77 | ENPP2 (0.67) | ENPP2CA1CA2ACHECES2 | |
| SCHEMBL28060965 | 0.77 | ENPP2 (0.85) | ENPP2CA1CA2ACHECYP3A4 | |
| SCHEMBL27951222 | 0.77 | ENPP2 (0.67) | ENPP2CA1CA2ACHECES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080167255-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2008-07-10 | — | — | US | disclosed |
| EP-1885694-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | Microbia, Inc. (US) | 2008-02-13 | — | — | EP | disclosed |
| US-7320972-B2 | 4-Biarylyl-1-phenylazetidin-2-ones | MICROBIA, INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1832576-A1 | 4-Biarylyl-1-phenolyzetidin-2-ones | Microbia Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1682499-B1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA INC (US) | 2007-08-08 | — | — | EP | disclosed |
| CN-1902169-A | 4-biaryl-1-phenylazetidin-2-ones | MICROBIA INC (US) | 2007-01-24 | — | — | CN | disclosed |
| WO-2006124713-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2006-11-23 | — | — | WO | disclosed |
| EP-1682499-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | Microbia, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| US-20050209165-A1 | 4-Biarylyl-1-phenylazetidin-2-ones | IRONWOOD PHARMACEUTICALS, INC. | 2005-09-22 | — | — | US | disclosed |
| WO-2005047248-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2005-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167255-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | APOB, CYP46A1, PCSK9 | ENPP2 2560/4885CA1 4882/4885CA2 4829/4885 |
| US-20050209165-A1 | 4-Biarylyl-1-phenylazetidin-2-ones | APOB, CYP46A1, PCSK9 | ENPP2 2560/4885CA1 4882/4885CA2 4829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.