Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | RRM2 | P31350 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.34 |
| ▸ | CDK2 | P24941 | 7/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL2355478 | 0.93 | CA12 (0.47) | CA12CA1CA2CA9RRM2 | |
| SCHEMBL461866 | 0.88 | CA12 (0.51) | CA12CA1CA2CA9RRM2 | |
| SCHEMBL2820178 | 0.88 | CA12 (0.51) | CA12CA1CA2CA9RRM2 | |
| Hydrochloric Acid SCHEMBL10483019 | 0.86 | CA12 (0.50) | CA12CA1CA2CA9RRM2 | |
| SCHEMBL476573 | 0.79 | CA12 (0.60) | CA12CA1CA2CA9RRM2 | |
| SCHEMBL4921793 | 0.74 | CA12 (0.55) | CA12CA1CA2CA9RRM2 | |
| SCHEMBL5958592 | 0.72 | ALDH1A1 (0.52) | CA12CA1CA2CA9RRM2 | |
| SCHEMBL99646 | 0.70 | CA12 (0.65) | CA12CA1CA2CA9RRM2 | |
| SCHEMBL11501100 | 0.66 | CA12 (0.52) | CA12CA1CA2CA9RRM2 | |
| SCHEMBL11115247 | 0.65 | KDM4E (0.64) | CA12CA1CA2CA9RRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416471-A1 | VULCANIZATION COMPOSITION FOR REDUCING ALLERGENIC POTENTIAL AND ELASTOMERIC ARTICLES FORMED THEREWITH | ALLEGIANCE CORPORATION | 2023-12-28 | — | — | US | disclosed |
| US-11780972-B2 | Vulcanization composition for reducing allergenic potential and elastomeric articles formed therewith | ALLEGIANCE CORPORATION (US) | 2023-10-10 | — | — | US | disclosed |
| EP-4233771-A2 | VULCANIZATION COMPOSITION HAVING REDUCED ALLERGENIC POTENTIAL | Allegiance Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| EP-2585289-B1 | VULCANIZATION COMPOSITION HAVING REDUCED ALLERGENIC POTENTIAL | ALLEGIANCE CORP (US) | 2023-06-07 | — | — | EP | disclosed |
| US-11242435-B2 | Vulcanization composition for reducing allergenic potential and elastomeric articles formed therewith | ALLEGIANCE CORPORATION (US) | 2022-02-08 | — | — | US | disclosed |
| US-20200339767-A1 | VULCANIZATION COMPOSITION FOR REDUCING ALLERGENIC POTENTIAL AND ELASTOMERIC ARTICLES FORMED THEREWITH | ALLEGIANCE CORPORATION | 2020-10-29 | — | — | US | disclosed |
| US-10759913-B2 | Vulcanization composition for reducing allergenic potential and elastomeric articles formed therewith | ALLEGIANCE CORPORATION (US) | 2020-09-01 | — | — | US | disclosed |
| US-10752738-B2 | Water-based resin composition and articles made therefrom | ALLEGIANCE CORPORATION (US) | 2020-08-25 | — | — | US | disclosed |
| US-10472110-B2 | Methods for packaging and sterilizing elastomeric articles and packaged elastomeric articles produced thereby | ALLEGIANCE CORPORATION (US) | 2019-11-12 | — | — | US | disclosed |
| US-20190292331-A1 | WATER-BASED RESIN COMPOSITION AND ARTICLES MADE THEREFROM | ALLEGIANCE CORPORATION (US) | 2019-09-26 | — | — | US | disclosed |
| US-20160355289-A1 | METHODS FOR PACKAGING AND STERILIZING ELASTOMERIC ARTICLES AND PACKAGED ELASTOMERIC ARTICLES PRODUCED THEREBY | ALLEGIANCE CORPORATION (US) | 2016-12-08 | — | — | US | disclosed |
| US-20160355288-A1 | METHODS FOR PACKAGING AND STERILIZING ELASTOMERIC ARTICLES AND PACKAGED ELASTOMERIC ARTICLES PRODUCED THEREBY | ALLEGIANCE CORPORATION (US) | 2016-12-08 | — | — | US | disclosed |
| US-9382023-B2 | Methods for packaging and sterilizing elastomeric articles, and packaged elastomeric articles produced thereby | ALLEGIANCE CORPORATION (US) | 2016-07-05 | — | — | US | disclosed |
| US-20160137868-A1 | VULCANIZATION COMPOSITION HAVING REDUCED ALLERGENIC POTENTIAL, AND ELASTOMERIC ARTICLES FORMED THEREWITH | ALLEGIANCE CORPORATION (US) | 2016-05-19 | — | — | US | disclosed |
| US-8980391-B2 | Vulcanization composition having reduced allergenic potential, and elastomeric articles formed therewith | ALLEGIANCE CORPORATION (US) | 2015-03-17 | — | — | US | disclosed |
| US-20130172445-A1 | WATER-BASED RESIN COMPOSITION AND ARTICLES MADE THEREFROM | ALLEGIANCE CORPORATION (US) | 2013-07-04 | — | — | US | disclosed |
| US-20120021155-A1 | VULCANIZATION COMPOSITION HAVING REDUCED ALLERGENIC POTENTIAL, AND ELASTOMERIC ARTICLES FORMED THEREWITH | ALLEGIANCE CORPORATION | 2012-01-26 | — | — | US | disclosed |
| US-20110203227-A1 | METHODS FOR PACKAGING AND STERILIZING ELASTOMERIC ARTICLES, AND PACKAGED ELASTOMERIC ARTICLES PRODUCED THEREBY | ALLEGIANCE CORPORATION (US) | 2011-08-25 | — | — | US | disclosed |
| US-20110178234-A1 | WATER-BASED RESIN COMPOSITON AND ARTICLES MADE THEREFROM | ALLEGIANCE CORPORATION (US) | 2011-07-21 | — | — | US | disclosed |
| US-20090234064-A1 | WATER-BASED RESIN COMPOSITION AND ARTICLES MADE THEREFROM | ALLEGIANCE CORPORATION (US) | 2009-09-17 | — | — | US | disclosed |