Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.78 |
| ▸ | HPGD | P15428 | 4/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.78 |
| ▸ | POLB | P06746 | 2/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.78 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29944351 | 0.88 | HPGD (1.00) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL30635500 | 0.85 | HPGD (0.90) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL4618663 | 0.83 | ALDH1A1 (0.78) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL27319478 | 0.83 | ALDH1A1 (0.82) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL63778 | 0.80 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL28900568 | 0.80 | HPGD (0.59) | ALDH1A1KDM4EHPGDHSD17B10ALOX15 | |
| SCHEMBL6099994 | 0.79 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL357927 | 0.79 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL31283651 | 0.79 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL209882 | 0.79 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |