Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.59 |
| ▸ | HPGDS | O60760 | 1/20 | 0.58 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.56 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618663 | 0.83 | ALDH1A1 (0.78) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL29944351 | 0.80 | HPGD (1.00) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL4618652 | 0.79 | ALDH1A1 (0.84) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL13663056 | 0.79 | EPHX2 (0.72) | — | |
| SCHEMBL5223723 | 0.78 | HRH3 (0.65) | HPGDSUSP30HRH3 | |
| SCHEMBL4734136 | 0.78 | EPHX2 (0.60) | HPGDSFRP1SMN1; SMN2PRKAA2 | |
| SCHEMBL12143441 | 0.78 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL30635500 | 0.78 | HPGD (0.90) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL4618172 | 0.78 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL14119500 | 0.76 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | ALDH1A1 1865/4885KDM4E 3044/4885HPGD 2925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.