Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPA | P23025 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PHGDH | O43175 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46709 | 0.83 | XPA (0.51) | XPAKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL27941201 | 0.64 | KMT2A (0.62) | ALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL16346518 | 0.64 | HPGD (0.53) | KDM4EALDH1A1HPGDPOLBTDP1 | |
| SCHEMBL3057812 | 0.64 | HPGD (0.69) | KDM4EALDH1A1LMNAHPGDNPC1 | |
| SCHEMBL3054179 | 0.64 | ALDH1A1 (0.70) | KDM4EALDH1A1LMNAHPGDMEN1 | |
| SCHEMBL23135764 | 0.63 | GAA (0.68) | ALDH1A1LMNAHPGDMEN1KMT2A | |
| SCHEMBL10099566 | 0.63 | NR1H4 (0.69) | LMNAKMT2AL3MBTL1 | |
| SCHEMBL4946307 | 0.63 | LMNA (0.57) | KDM4EALDH1A1LMNAHPGDPOLB | |
| Fluorobenzene SCHEMBL27605534 | 0.62 | KMT2A (0.55) | KDM4EALDH1A1LMNAHPGDPOLB | |
| SCHEMBL684546 | 0.62 | ENPP2 (1.00) | KDM4EALDH1A1LMNAHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012005800-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRIN CD11B/CD18 | ADHAERE PHARAMACEUTICALS, INC. (US) | 2012-01-12 | — | — | WO | disclosed |