Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPA | P23025 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | PHGDH | O43175 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46717 | 0.85 | ALDH1A1 (0.58) | XPATDP1POLBL3MBTL1MEN1 | |
| SCHEMBL46199 | 0.83 | XPA (0.48) | XPATDP1POLBL3MBTL1MEN1 | |
| SCHEMBL46214 | 0.77 | TDP1 (0.52) | TDP1POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL46230 | 0.68 | MAPT (0.50) | POLBMEN1KMT2ANPC1RAB9A | |
| SCHEMBL2557746 | 0.66 | KDM4E (1.00) | TDP1POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL6391164 | 0.65 | TDP1 (0.83) | XPATDP1POLBL3MBTL1MEN1 | |
| SCHEMBL6391161 | 0.65 | TDP1 (0.83) | XPATDP1POLBL3MBTL1MEN1 | |
| SCHEMBL10099566 | 0.65 | NR1H4 (0.69) | L3MBTL1KMT2ALMNA | |
| SCHEMBL684546 | 0.65 | ENPP2 (1.00) | TDP1POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL20339613 | 0.64 | ENPP2 (0.66) | XPATDP1POLBL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012005800-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRIN CD11B/CD18 | ADHAERE PHARAMACEUTICALS, INC. (US) | 2012-01-12 | — | — | WO | disclosed |