Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 2/20 | 0.41 |
| ▸ | LIG1 | P18858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2219521 | 0.87 | HPGD (0.66) | HPGDALDH1A1MAPK1HTTMEN1 | |
| SCHEMBL1520406 | 0.81 | ALDH1A1 (0.47) | HPGDALDH1A1HTTMEN1KMT2A | |
| SCHEMBL1923931 | 0.81 | ALDH1A1 (0.46) | HPGDALDH1A1MAPK1HTTMEN1 | |
| SCHEMBL28771891 | 0.81 | PTGDR2 (0.49) | HPGDALDH1A1HTTPTGDR2TSHR | |
| SCHEMBL23748178 | 0.80 | MAPT (0.45) | HPGDALDH1A1MAPK1HTTTSHR | |
| SCHEMBL3694739 | 0.80 | ERN1 (0.41) | HPGDALDH1A1MAPK1HTTPTGDR2 | |
| SCHEMBL3954852 | 0.80 | GAA (0.41) | HPGDALDH1A1MAPK1HTTTSHR | |
| SCHEMBL10158234 | 0.80 | ERN1 (0.40) | HPGDALDH1A1MAPK1HTTTSHR | |
| SCHEMBL2523798 | 0.80 | GAA (0.55) | HPGDALDH1A1MAPK1HTTMEN1 | |
| SCHEMBL28607462 | 0.80 | ALDH1A1 (0.43) | HPGDALDH1A1MAPK1HTTPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024254601-A1 | HPGD INHIBITORS AND USES THEREOF | NIMBUS DISCOVERY, INC. (US) | 2024-12-12 | — | — | WO | disclosed |
| CN-116789626-A | Preparation method of aromatic chroman-4-one compound containing amide group | 湖南科技学院 | 2023-09-22 | — | — | CN | disclosed |
| US-20080280836-A1 | Anti-hypercholesterolemic biaryl azetidinone compounds | MORRIELLO GREGORI J | 2008-11-13 | — | — | US | disclosed |
| US-20080280836-A1 | Anti-hypercholesterolemic biaryl azetidinone compounds | MORRIELLO GREGORI J | 2008-11-13 | — | — | US | disclosed |
| US-20080280836-A1 | Anti-hypercholesterolemic biaryl azetidinone compounds | MORRIELLO GREGORI J | 2008-11-13 | — | — | US | disclosed |
| US-20080167255-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2008-07-10 | — | — | US | disclosed |
| EP-1885694-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | Microbia, Inc. (US) | 2008-02-13 | — | — | EP | disclosed |
| US-7320972-B2 | 4-Biarylyl-1-phenylazetidin-2-ones | MICROBIA, INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1832576-A1 | 4-Biarylyl-1-phenolyzetidin-2-ones | Microbia Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1682499-B1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA INC (US) | 2007-08-08 | — | — | EP | disclosed |
| CN-1902169-A | 4-biaryl-1-phenylazetidin-2-ones | MICROBIA INC (US) | 2007-01-24 | — | — | CN | disclosed |
| WO-2006124713-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2006-11-23 | — | — | WO | disclosed |
| EP-1682499-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | Microbia, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| US-20050209165-A1 | 4-Biarylyl-1-phenylazetidin-2-ones | IRONWOOD PHARMACEUTICALS, INC. | 2005-09-22 | — | — | US | disclosed |
| WO-2005047248-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2005-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167255-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | APOB, CYP46A1, PCSK9 | HPGD 2215/4885ALDH1A1 848/4885MAPK1 2917/4885 |
| US-20080280836-A1 | Anti-hypercholesterolemic biaryl azetidinone compounds | APOB, PCSK9, CYP46A1 | HPGD 2837/4885ALDH1A1 1045/4885MAPK1 2790/4885 |
| US-20050209165-A1 | 4-Biarylyl-1-phenylazetidin-2-ones | APOB, CYP46A1, PCSK9 | HPGD 2215/4885ALDH1A1 848/4885MAPK1 2917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.