Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 9/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | IGFBP5 | P24593 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4620353 | 1.00 | ALOX15 (0.43) | ALOX15ALDH1A1PDE10ADHODHGAA | |
| SCHEMBL5704021 | 0.99 | ALOX15 (0.42) | ALOX15ALDH1A1PDE10ADHODHGAA | |
| SCHEMBL5704026 | 0.92 | ALDH1A1 (0.40) | ALOX15ALDH1A1PDE10ADHODHIDO1 | |
| SCHEMBL5704033 | 0.92 | ALDH1A1 (0.40) | ALOX15ALDH1A1PDE10ADHODHIDO1 | |
| SCHEMBL14255066 | 0.91 | IGFBP5 (0.39) | ALOX15ALDH1A1PDE10ADHODHGAA | |
| SCHEMBL4622456 | 0.91 | ALDH1A1 (0.37) | ALOX15ALDH1A1PDE10ADHODHGAA | |
| SCHEMBL4622498 | 0.90 | TSHR (0.42) | ALOX15ALDH1A1PDE10ADHODHGAA | |
| SCHEMBL4621902 | 0.87 | ALOX15 (0.42) | ALOX15ALDH1A1PDE10ADHODHIDO1 | |
| SCHEMBL4620763 | 0.85 | PDE10A (0.52) | ALOX15ALDH1A1PDE10ADHODHGAA | |
| SCHEMBL5097600 | 0.83 | ALOX15 (0.42) | ALOX15ALDH1A1PDE10ADHODHGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | claimed |
| EP-1696924-B1 | ACIDIC QUINOLINE DERIVATIVES AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF HYPERGLYCAEMIA-RELATED PATHOLOGIES | MERCK PATENT GMBH (DE) | 2008-03-26 | — | — | EP | claimed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| EP-1696924-B1 | ACIDIC QUINOLINE DERIVATIVES AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF HYPERGLYCAEMIA-RELATED PATHOLOGIES | MERCK PATENT GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |
| EP-1696924-A1 | ACIDIC QUINOLINE DERIVATIVES AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF HYPERGLYCAEMIA-RELATED PATHOLOGIES | MERCK PATENT GmbH (DE) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005063244-A1 | ACIDIC QUINOLINE DERIVATIVES AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF HYPERGLYCAEMIA-RELATED PATHOLOGIES | MERCK PATENT GMBH (DE) | 2005-07-14 | — | — | WO | disclosed |