Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622034 | 0.87 | GAA (0.53) | GAAALDH1A1L3MBTL1POLBMEN1 | |
| SCHEMBL8633892 | 0.85 | SHMT2 (0.70) | GAAALDH1A1L3MBTL1POLBMEN1 | |
| SCHEMBL17034742 | 0.84 | SHMT2 (0.69) | GAAALDH1A1L3MBTL1POLBMEN1 | |
| SCHEMBL6947831 | 0.82 | SHMT2 (0.58) | GAAALDH1A1L3MBTL1POLBMEN1 | |
| SCHEMBL13597563 | 0.82 | GAA (0.56) | GAAALDH1A1L3MBTL1POLBMEN1 | |
| SCHEMBL6953402 | 0.80 | GAA (0.60) | GAAALDH1A1L3MBTL1POLBMEN1 | |
| SCHEMBL4619249 | 0.78 | SHMT2 (0.54) | GAAALDH1A1L3MBTL1POLBMEN1 | |
| SCHEMBL13597571 | 0.78 | POLB (0.76) | GAAALDH1A1L3MBTL1POLBMEN1 | |
| SCHEMBL5462191 | 0.77 | MAPT (0.54) | GAAALDH1A1L3MBTL1POLBMEN1 | |
| SCHEMBL643536 | 0.77 | POLB (0.75) | GAAALDH1A1L3MBTL1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1905762-A1 | PYRAZOLONE DERIVATIVE | Genecare Research Institute Co., Ltd (JP) | 2008-04-02 | — | — | EP | disclosed |
| EP-1900728-A1 | PHARMACEUTICAL COMPOSITION COMPRISING PYRAZOLONE DERIVATIVE | Genecare Research Institute Co., Ltd (JP) | 2008-03-19 | — | — | EP | disclosed |