Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 4/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4621074 | 0.88 | NPC1 (0.40) | SMN1; SMN2MAPTNPC1ALDH1A1LMNA | |
| SCHEMBL2246521 | 0.88 | HTR7 (0.40) | SMN1; SMN2MAPTNPC1ALDH1A1LMNA | |
| SCHEMBL4623203 | 0.88 | NPC1 (0.43) | SMN1; SMN2MAPTNPC1ALDH1A1LMNA | |
| SCHEMBL4622938 | 0.87 | HTR7 (0.39) | SMN1; SMN2MAPTNPC1ALDH1A1LMNA | |
| SCHEMBL5653519 | 0.85 | CYP1A2 (0.44) | SMN1; SMN2MAPTHDAC3MAPK1ADRA1A | |
| SCHEMBL2248130 | 0.82 | TAS2R14 (0.39) | SMN1; SMN2MAPTNPC1ALDH1A1LMNA | |
| SCHEMBL5653109 | 0.81 | SRD5A2 (0.47) | LPAR1PTGDR2MMP2 | |
| SCHEMBL5651545 | 0.80 | MMP12 (0.44) | SMN1; SMN2MAPTALDH1A1LMNARAB9A | |
| SCHEMBL2244942 | 0.75 | NPC1 (0.42) | SMN1; SMN2MAPTNPC1ALDH1A1LMNA | |
| SCHEMBL4623232 | 0.73 | HTR7 (0.38) | SMN1; SMN2MAPTNPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | disclosed |