Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 4/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4621072 | 0.88 | SMN1; SMN2 (0.40) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL2246521 | 0.76 | HTR7 (0.40) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL4622938 | 0.75 | HTR7 (0.39) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL4623203 | 0.75 | NPC1 (0.43) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL5653519 | 0.72 | CYP1A2 (0.44) | MAPTSMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL2248130 | 0.70 | TAS2R14 (0.39) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL4371351 | 0.69 | KMT2A (0.40) | ALDH1A1LMNASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL2249427 | 0.69 | CA2 (0.59) | NPC1RAB9AMAPTALDH1A1HTR7 | |
| SCHEMBL5653109 | 0.68 | SRD5A2 (0.47) | LPAR1 | |
| SCHEMBL4621965 | 0.68 | TRIM24 (0.37) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | disclosed |