Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.47 |
| ▸ | CA9 | Q16790 | 14/20 | 0.47 |
| ▸ | CA1 | P00915 | 14/20 | 0.47 |
| ▸ | CA12 | O43570 | 13/20 | 0.47 |
| ▸ | CA7 | P43166 | 9/20 | 0.47 |
| ▸ | CA5A | P35218 | 8/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 8/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.47 |
| ▸ | CA6 | P23280 | 7/20 | 0.47 |
| ▸ | CA4 | P22748 | 7/20 | 0.47 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.47 |
| ▸ | CA3 | P07451 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL898460 | 0.81 | ALDH1A1 (0.46) | CA2CA9CA1CA12CA7 | |
| SCHEMBL9450366 | 0.78 | CA2 (0.56) | CA2CA9CA1CA12CA7 | |
| SCHEMBL38651153 | 0.77 | NR1I2 (0.60) | CA2CA9CA1CA12CA7 | |
| SCHEMBL20032091 | 0.76 | CA2 (0.55) | CA2CA9CA1CA12CA7 | |
| SCHEMBL31010761 | 0.75 | NR1I2 (0.63) | CA2CA9CA1CA12CA7 | |
| SCHEMBL20372807 | 0.74 | NR1I2 (0.54) | CA2CA9CA1CA12CA7 | |
| SCHEMBL3091350 | 0.73 | CA2 (0.56) | CA2CA9CA1CA12CA7 | |
| SCHEMBL18713704 | 0.72 | CA2 (0.59) | CA2CA9CA1CA12CA14 | |
| SCHEMBL28246182 | 0.72 | CA2 (0.51) | CA2CA9CA1CA12CA7 | |
| SCHEMBL14043148 | 0.71 | CA2 (0.54) | CA2CA9CA1CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789699-A1 | SPIRO HETEROCYCLE-IMIDAZO(1,2-a]INDENO(1,2-e]PYRAZINE]-4'-ONES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1997-08-20 | — | — | EP | claimed |
| WO-1996014318-A1 | SPIRO[HETEROCYCLE-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE]-4'-ONES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1996-05-17 | — | — | WO | claimed |
| EP-1883632-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | Amgen Inc. (US) | 2008-02-06 | — | — | EP | disclosed |
| WO-2006116563-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2006-11-02 | — | — | WO | disclosed |
| WO-2006106241-A1 | PIPERAZINE DERIVATIVES AND USE THEREOF AS SEROTONIN REUPTAKE INHIBITORS OR AS NEUROKININ ANTAGONISTS | LES LABORATOIRES SERVIER (FR) | 2006-10-12 | — | — | WO | disclosed |